SupplementLibrary

Heart Tension
Dr. Heather Boyd-Roberts

Heart Tension™ formula is a highly effective combination of vitamins, minerals, amino acids, and botanical medicines that have been clinically shown to lower blood pressure.

Rauwolfia
Rauwolfia is a powerful botanical that acts as a hypotensive agent by reducing heart rate and also has anti-arrhythmic effects (meaning it lowers blood pressure and supports rhythmic heart beats). A plant in the periwinkle family, Rauwola contains over 50 alkaloids (resperine, rescinnamine, and desperidine), which have been well researched in the area of blood pressure. Rauwola demonstrates hypotensive, sedative, and tranquilizing effects (7), reduces heart rate (11), has antiarrhythmic effects (12), and causes a general sense of euphoria (11).

Coleus Forskohlii (95% Forskolin)
Coleus forskohlii supports blood pressure and a healthy heart by activating adenylate cyclase and cyclic monophosphate (cAMP). Increased production of cAMP causes calcium channels to open and intracellular calcium concentrations to increase, resulting in increased contractility of heart muscle and relaxation of smooth muscle (1). cAMP is also known to support heart muscle contraction, which helps reduce stress on the heart. Forskolin is the active ingredient/constituent and produces the heart related therapeutic effects of Coleus forskohlii. It increases the effectiveness of the heart muscle resulting in a more powerful heartbeat and widens blood vessels thereby lowering blood pressure. The higher the percentage of forskolin contained the greater the therapeutic effect.

Grape Seed Extract (95% Proanthocyanidins)
Grape seed extract is an excellent source of oligomeric proanthocyanidin complexes (OPCs) which are a type of antioxidant that encourages vasodilatory action (opens arteries). A 2006 published study from the University of California at Davis showed that Grape seed extract helped control blood pressure in the control group taking 150mg per day. Systolic pressure dropped 12 points on average while diastolic blood pressure dropped an average of 8 points. Researcher C. Tissa Kappagoda, MD,PhD stated her research team believed Grape seed extract might dilate blood vessels (2). Grape seeds are an excellent source of vitamin E, linoleic acid, flavonoids and oligomeric proanthocyanidin complexes (OPCs), which are a type of antioxidant. In addition to vascular health support, other health benets of Grape seed extract are prevention of cognitive decline, reduction of inflammation, lowering the incidence of skin cancers, improvement of wound healing and bone strength.

Garlic
Garlic is mostly used for its antihyperlipidemic, antihypertensive, and anti-fungal effects. The applicable part of garlic is the bulb. Many of the pharmacological effects of garlic are attributed to the allicin, ajoene and other organosulfur constituents such as S-allyl-L-cysteine. For hypertension, garlic is thought to reduce blood pressure by causing smooth muscle relaxation and vasodilation by activating production of endothelium derived relaxation factor (EDRF, nitric oxide) (3).

Hawthorn Berry
Hawthorn berry contains the active constituents that include flavonoids, such as vitexin, rutin, quercetin and hyperoside and oligomeric proanthocyanidins (OPC’s) such as epicatechin and procyanidins. Hawthorn berry (Crataegus) has hypotensive and anti arrhythmic activity (4). In a clinical study of patients with coronary perfusion disorders, 77% of those who were given Crataegus experienced an observable decrease of ischemia reaction to exercise.

Gynostemma Pentaphyllum (Jiaogulan)
Gynostemma contains 82 distinct saponins that are referred to as gypenosides. Each of these gypenosides has a unique property that gives it a therapeutic significance. The gypenosides medicinal qualities range
from lowering cholesterol, improving oxygen absorption, and increasing cardiac output by increasing stroke volume and not through increasing the heart rate (5).

Magnesium
Magnesium is involved with more than 300 enzyme systems as well as playing an essential role in more than 300 cellular reactions (10). Our bodies contain 25 grams (less than one ounce) of magnesium. Magnesium is required for the formation of cyclic AMP (cAMP) and is
involved in ion movements across cell membranes. In cell membranes, a decreased concentration of magnesium and an increased calcium to magnesium ratio has been associated with hypertension (6).

Potassium
Potassium is a mineral that plays a role in many body functions including acid-base balance, electrodynamic characteristics of the cell, isotonicity, and various enzymatic reactions (7). Potassium is required for normal blood pressure. Potassium depletion occurs when deficient levels of magnesium are present in cardiac and vascular muscle cells. Without adequate stores of magnesium, potassium is not retained.

Vitamin C
Vitamin C is a commonly used water-soluble vitamin that acts as an antioxidant and free radical scavenger. Studies show that when plasma Vitamin C levels are low both systolic and diastolic blood pressure increases (8). Vitamin C has been shown to promote normal endothelial function (9). Niacin and Inositol (from Inositol Hexanicotinate) Inositol hexanicotinate consists of six molecules of niacin chemically linked to an inositol molecule. It is hydrolyzed in the body to free niacin and inositol, although this occurs slowly, with peak serum levels not occurring until about 10 hours after ingestion, which reduces the incidence of the flushing associated with niacin. Orally taking Inositol Hexanicotinate reduces serum lipid levels (10). Niacin is a vasodilator, which increases the diameter of the blood vessels, which leads to lowering the blood pressure.

Patients: Consult with your healthcare professional
for the proper dosage and use of this formula.

These statements have not been evaluated by the Food and Drug Administration.This product is not intended to diagnose, treat, cure or prevent any disease.

Heart Tension™
In many instances, high blood pressure is an early sign of serious cardiovascular disease. Elevated blood pressure is generally regarded as the greatest risk factor for stroke. Over sixty million Americans have hypertension and more than half of all Americans aged sixty-ve to seventy-four years old suffer from high blood pressure. Studies and medical experts agree that non-drug therapies should be used rather than pharmaceutical drugs in the treatment of borderline-to-moderate hypertension. Heart Tension™ formula offers a safe and effective alternative from the pharmaceutical drugs that pose significant health risks. Heart Tension™ formula is a unique blend of key nutrients
and proven botanical medicines that have been clinically shown to improve heart function and lower blood pressure.


USE HEART TENSION™ ONLY UNDER THE GUIDANCE OF A
LICENSED HEALTHCARE PROVIDER. Please monitor patients
closely. Rauwolfia serpentina is a highly effective hypotensive.
Rauwolfia serpentina reduces heart rate, has anti-arrhythmic and
sedative effects. Potential adverse reactions may include fatigue,
slowed reflexes, and bradycardia. A small percentage of patients
may develop mental depression. Concomitant use with alcohol
may increase the risk of CNS-depressant effects. DO NOT USE
with MAO (monoamine oxidase) inhibitors. DO NOT USE in pregnancy, breastfeeding or depression. If patients report any of these sytmptoms, lower the dosage, continue to monitor closely, and discontinue use if adverse conditions persist.

S u p p l e m e n t F a c t s
Serving size: 3 capsules
Servings per container: 30
Amount per serving %DV
Magnesium (as Citrate-Malate) 255 mg 66%
Vitamin B3 (as Niacin) (from Inositol Hexanicotinate) 156 mg 790%
Vitamin C (as Poly C Ascorbate) 105 mg 300%
Hawthorn berry dry extract (Crataegus spp) (>2% vitexins) 300 mg *
Garlic extract (Allium sativum) (1% allicin) (bulb) 150 mg *
Grape seed extract (Vitis spp) (95% proanthocyanidins) 100 mg *
Potassium (as Citrate-Malate) 105 mg 3%
Rauwolfia spp (root) 75 mg *
Inositol (from Inositol Hexanicotinate) 49 mg *
Coleus forskohlii extract (95% Forskolin) (root) 6 mg *
Gynostemma pentaphyllum extract (as Jiaogulan)
(20% gypenosides) (whole herb) 60 mg *
Percent Daily Values are based on a 2,000 calorie diet.
* Daily Value not established.
Other ingredients: Vegetarian capsules (cellulose and water), l-Leucine


REFERENCES:
1. Eur J Pharmacol 1985;111:1-8
2. Slvaprakasapillai B, Edirisinghe I, Randolf J, Steinberg F, Kappagoda T. “Effect of Grape seed extract on blood pressure.”
Metabolism. 2009 58(12):1743-6.
3. Life Sci 1998;62:71-77
4. J Clin Pharmacol 2002;42:605-12
5. Takemoto, Tsunematsu et al. Studies of the constituents of Gynostemma pentaphyllum Makino. 1. Structures of Gypenosides I-XIV.
Yakugakuzasshi 1983;103(2):173-185
6. Am J Hypertens 2001;14:254-8.
7. McKevoy GK, ed AHFS Drug information. Bethesda, MD: American Society of Health System Pharmacists, 1998
8. Circ Res 2000; 87:349-54
9. Circulation 2001;104:2182-7
10. Altern Med Rev 1998;3:222-3.
11. Robbers, JE., SPeedie, MK., Tyler, VE., Pharmacognosy and Pharmacobiotechnology, Baltimore, MD:Williams & Wilkins 1996
12. Gruenwald, J., Brendler, T., Jaenicke, C., PDR for Herbal Medicines, 1st ed., Montvale, NJ: Medical Economics Company, Inc., 1998